13. September 2021, Online via Zoom
Plant signal transduction cascades – from atoms to phenotypes and back
Speaker: Prof. Michael Hothorn, University of Geneva
Host: Prof. Dr. Antonia Neels, President of the Swiss Society for Crystallography SSCr
Details about the talk will follow soon.
About the speaker:
Dimitrios José Fotiadis is professor of structural biology at the Institute of Biochemistry and Molecular Medicine, University of Bern, where he has established "The Fotiadis laboratory", focusing on the function, structure and supramolecular organization of membrane proteins. To this aim, biochemical and biophysical approaches as well as high-resolution microscopy and crystallography techniques are used.
He holds a PhD in biochemistry with the subject and the title of “Biochemical and structural analyses of membrane proteins in plants and animals” from the University of Basel in 2000.
During his postdoc in the group of Prof. Andreas Engel at the Biozentrum of the University of Basel, Dimitrios Fotiadis unsettled the dogma that the light receptor protein rhodopsin is monomeric in the retinal rod outer segments by direct visualization of rhodopsin dimers and higher oligomers in native disk membranes using electron and particularly atomic force microscopy. Furthermore, these results on the oligomeric state of rhodopsin were corroborated by biochemical and biophysical methods in Basel and during Dimitrios Fotiadis’ scientific stay in Kris Palczewski’s laboratory (University of Washington, Seattle, USA). Importantly, rhodopsin is just one example of a G protein-coupled receptor (GPCR) of which more than a thousand exist in the human body.
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