October 20, 2010 11:00 - 0:00
Empa, St. Gallen, Lerchenfeldstr. 5, C 3.11
The delivery of drugs is an old but still relevant issue. To improve the patients compliance facile application is always favorable such as oral administration. The skin as the largest human organ is also very easily accessible for application but also for unintended contamination. In this context, the ability of active substances (drugs or noxious agents) to cross the human skin is an important aspect. For drugs a phenomenological model was established also tested with relevant in vitro models based on human skin. Here the lipophilicity and the size are the key features what should hold true also for particulate formulations. The influence of nanoparticulate drug formulations on drug permeation could be shown to depend on the material of the particles. However, the potential of ultra-small particles to penetrate and permeate the skin is a still controversially discussed topic. Quantum dots and colloidal gold in combination with the use of multiphoton and confocal microscopy seem to be a valid and promising approach to shed light onto this issue.
The language of the presentation is English.
Free entrance, guests are welcome
Dr. Anne Satir
Tel: 044 823 4562