November 9, 2011 11:00 - 12:00
Empa, St. Gallen, C 3.11
The skin, which serves as a protective barrier against the environment, is frequently exposed to harmful insults that induce the formation of reactive oxygen species (ROS). Excessive levels of ROS are deleterious, as they damage cellular macromolecules, including DNA. As a consequence, skin aging occurs and the incidence of skin cancer increases with the extent of UV exposure. To cope with ROS and the consequent damage, cells have evolved various antioxidant defense mechanisms. One of the central players in the ROS defense is the transcription factor Nrf2, which regulates the expression of numerous detoxifying enzymes and antioxidant proteins. Therefore, we studied the consequences of Nrf2 gain or loss-of-function in the skin. We identified a remarkable protective role of Nrf2: Loss of this transcription factor caused impaired wound healing, enhanced the UV sensitivity of the skin and increased the rate of skin carcinogenesis in two different tumor models. To determine if Nrf2 activation is beneficial, we used a pharmacological and a genetic strategy to activate Nrf2 in keratinocytes. Our results reveal positive as well as negative consequences of Nrf2 activation that need to be considered when Nrf2 activating compounds are used for skin protection under stress conditions.
The language of the presentation is English.
Free entrance, guests are welcome
Dr. Anne Satir
Tel: 058 765 4562